Do you get erections during masturbation, with a partner or while you sleep? Oral ED medicines might not work or might be dangerous if you also take any of the following: Nitrate medicines. More Information Erectile dysfunction dietary supplements Coping and support Whether the cause is physical, psychological or a combination of both, erectile dysfunction can become a source of mental and emotional stress for you and your partner. Vardenafil usually works for 4 to 5 hours. Men were also turning to unlicensed and potentially harmful remedies, such as Kamagra an oral jelly that claims falsely to contain the same ingredients as Viagra.Sildenafil (Viagra) is used to treat erectile dysfunction (impotence; inability to get or keep an erection) in men. Sildenafil (Liqrev, Revatio) is used to improve the ability to exercise . 1. It Targets the Problem and Works Quickly. Being a topical means MED targets your penis directly and offers a “quick onset of action,” Dr. Pearlman . Sildenafil (Viagra). Tadalafil (Cialis). Vardenafil. These medicines are called PDE5 inhibitors. They enhance the effects of a chemical the body makes that relaxes .