Which Lasts Longer? The medication should be taken once daily at about the same time every day to maintain a consistent level of medicine in the body. Healthcare providers have experience talking about ED and providing treatment options without any judgment or shame. In addition, ED is extremely common. Some may find that Cialis works in two hours and takes the medicine two hours before sexual activity. Because they are the same class of medications, they have similar side effects and effectiveness. The pill should be swallowed whole and not crushed, broken, or chewed.Cialis comes in several different strengths, including: milligrams (mg) 5 mg. 10 mg. 20 mg. The cost for these different strengths depends on whether you have insurance, your individual plan. Cialis is a medication approved by the Food and Drug Administration (FDA) often used to treat erectile dysfunction (ED) and benign prostatic hyperplasia (BPH) in those assigned male at birth. Get started. Get Cialis and Tadalafil pill online. Try the generic Cialis option for a fraction of the cost, after speaking with one of our online medical professionals.