In vivo studies: No significant interactions were shown with tolbutamide mg or warfarin 40 mg , both of which are metabolized by CYP2C9. It is eliminated predominantly by hepatic metabolism mainly CYP3A4 and is converted to an active metabolite with properties similar to the parent, sildenafil. VIAGRA improved these aspects of sexual function: frequency, firmness and maintenance of erections; frequency of orgasm; frequency and level of desire; frequency, satisfaction and enjoyment of intercourse; and overall relationship satisfaction. As in the other titration studies, patients were started on 50 mg and allowed to adjust the dose up to mg or down to 25 mg of VIAGRA; all patients, however, were receiving 50 mg or mg at the end of the study. If it is not treated right away, priapism can permanently damage your penis sudden vision loss in one or both eyes. Sexual function data were also recorded by patients in a daily diary. VIAGRA was evaluated primarily at doses of 25 mg, 50 mg and mg in 21 randomized, double-blind, placebo-controlled trials of up to 6 months in duration, using a variety of study designs fixed dose, titration, parallel, crossover.The Savings Offer and Program expire on 12/31/ For further information, call , visit test1.ru, or write: Viatris Inc., P.O. Box , Mission, KS . Typical dosing for Sildenafil (Viagra) The typical dose is to take 50 mg of sildenafil (Viagra) by mouth, about 1 hour before sex, as needed. The maximum . The maximum dose of Viagra is mg each day. Doses above the maximum dose, such as mg per day, will increase the risk of side effects. And in .