Vardenafil comes as a tablet and a rapidly disintegrating dissolves in the mouth and is swallowed without water tablet to take by mouth. An orally disintegrating form, marketed as Staxyn and Levitra Soft, has been gaining approvals in countries such as the United States [10] and Canada. Grapefruit and Seville oranges may interact with vardenafil and cause side effects. This medicine does not prevent the spread of sexually transmitted diseases such as human immunodeficiency virus HIV. It is usually taken as needed, with or without food, 60 minutes before sexual activity. An erection will not occur just by taking a pill.VARDENAFIL (var DEN a fil) treats erectile dysfunction (ED). It works by increasing blood flow to the penis, which helps to maintain an erection. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. COMMON BRAND NAME(S): Levitra. What is vardenafil? Vardenafil is used in adult men to treat erectile dysfunction (impotence). Vardenafil may also be used for purposes not listed in this medication guide. Vardenafil is used to treat erectile dysfunction (impotence; inability to get or keep an erection) in men. Vardenafil is in a class of medications called phosphodiesterase (PDE) inhibitors. It works by increasing blood flow to the penis during sexual stimulation.