Do you have premature ejaculation every time you have sex? Or tighten the muscles that keep you from passing gas. Manufacturer advises avoid with concurrent use of potent inhibitors of CYP3A4 except in patients verified to be extensive CYP2D6 metabolisers where manufacturer recommends max. The summary of product characteristics states that patients should be advised not to use dapoxetine in combination with recreational drugs or alcohol. Premature ejaculation can occur in conjunction with erectile dysfunction and the European Association of Urology guidelines on male sexual dysfunction states that if premature ejaculation is secondary to erectile dysfunction then the erectile dysfunction should be treated before or at the same time as the premature ejaculation. Behavioral techniques In some cases, therapy for premature ejaculation involves simple steps. FDB Multilex and those who are responsible for their construction, operation and maintenance do not know the particular circumstances, condition or medical history of particular patients or groups of patients and so cannot advise as to particular cases.Average: Monoisotopic: Chemical Formula C 21 H 23 NO Synonyms Dapoxetina Dapoxetine Dapoxetinum External IDs LY LY Pharmacology Indication For the treatment of premature ejaculation. Build, train, & validate predictive machine-learning models with structured datasets. See how Associated .  · Medscape UK – Indication-specific dosage for Dapoxetine oral, precautions and warnings, side effects, pregnancy and lactation, contraindications and full drug monograph. Adult Initially 30 mg, to be taken approximately 1–3 hours before sexual activity, subsequent doses adjusted according to response; review treatment after 4 weeks (or 6 doses) and at least every 6 months thereafter, not recommended for adults 65 years and over; maximum 1 dose per day; maximum 60 mg per day. Dose adjustments due to interactions.